RUO - FP054 MDM2 Gene Amplification Probe Detection Kit

Cat.# FP-054: MDM2 Gene Amplification Probe  Detection Kit (RUO)

[Overview] 

This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.

                              

[Download] MDM2 Gene Amplification Probe Instructions