RUO - FP242 BCL2/IGH t(14;18) Gene Fusion Probe Detection Kit

Cat.# FP-242-4: BCL2/IGH t(14;18) Gene Fusion Probe Detection Kit (RUO)

[Overview] 

IGH (Immunoglobulin Heavy Locus) is a Protein Coding gene. Diseases associated with IGH include Agammaglobulinemia 1, Autosomal Recessive and Follicular Lymphoma 1. Among its related pathways are Immune response CD16 signaling in NK cells and Immune response Lectin induced complement pathway.

BCL2 (BCL2 Apoptosis Regulator) is a Protein Coding gene. Diseases associated with BCL2 include Follicular Lymphoma 1 and High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit. Among its related pathways are Apoptosis and survival-Anti-apoptotic action of nuclear ESR1 and ESR2 and Estrogen signaling pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and identical protein binding. 

The majority of patients with follicular lymphoma and a subset of patients with diffuse large B-cell lymphoma (DLBCL) have a translocation between chromosomes 14 and 18 which results in the fusion of the immunoglobulin heavy chain gene (IGH), located at chromosome region 14q32, with the BCL2 gene, located at chromosome region 18q21.

                                              

[Download] BCL2/IGH t(14;18) Gene Fusion Probe Instructions