ERBB2 gene (17q12-q21.1) labeled as orange, with a length of 300 kb; 17 chromosome centromere (CEP17) labeled as green.
Overview
Human HER2 gene amplification probe is used to determine the copy number status of the HER2/neu (ERBB2) gene in cancer tissue, primarily breast and gastric carcinomas. Identifying HER2 amplification is critical for selecting patients likely to benefit from targeted therapies like trastuzumab (Herceptin).