ABL gene (9q34.11-13) labeled as orange, with a length of 600 kb; BCR gene (22q11.22-23) labeled as green, with a total length of 1000 kb.
Overview
BCR/ABL gene fusion probe is used to identify the Philadelphia chromosome—a reciprocal translocation between chromosomes 9 and 22. This abnormal fusion creates the BCR-ABL1 oncogene, which is the hallmark of Chronic Myeloid Leukemia (CML) and is also found in Acute Lymphoblastic Leukemia (ALL).