TMPRSS2 gene (21q22) labeled as orange; , ETV4 gene (17q21) labeled as green.
Overview
A TMPRSS2/ETV4 gene anomaly probe is used to identify the chromosomal translocation between the TMPRSS2 gene (21q22.3) and the ETV4 gene (17q21). This fusion is part of the ETS-family rearrangements found in prostate cancer, though it occurs less frequently than the ERG or ETV1 variants.