P53 gene (17p13.1) labeled as orange, with a length of 185 kb; 17 chromosome centromere (CEP17) labeled as green.
Overview
P53 gene probe is used to detect the deletion of the 17p13.1 locus, where the TP53 tumor suppressor gene is located. In Chronic Lymphocytic Leukemia (CLL), identifying this deletion is the most critical step for determining prognosis and treatment resistance.