D13S319 gene locus (13q14.2) labeled as orange, with a length of 160 kb; 12 chromosome centromere (CEP12) labeled as green.
Overview
D13S319 gene probe is used to detect deletions of the 13q14.3 locus. This is the most common genetic abnormality in Chronic Lymphocytic Leukemia (CLL), occurring in more than 50% of cases. While primarily known for its role in Chronic Lymphocytic Leukemia (CLL), it is also used to evaluate other B-cell malignancies like Multiple Myeloma and Mantle Cell Lymphoma.