MYH11 gene (16p13.11) labeled as green, with a length of 699 kb; CBFB gene (16q22.1) labeled as orange, with a length of 605 kb.
Overview
CBFB/MYH11 gene fusion probe is used to detect the inv(16)(p13; q22) or t(16; 16)(p13; q22) chromosomal rearrangements that fuse CBFB gene (16q22) with MYH11 gene (16p13), creating a chimeric protein, a hallmark of Acute Myeloid Leukemia (AML) M4Eo subtype.