MDM4 gene (1q32) labeled as orange, with a length of 450 kb; 1q21 labeled as green, with a length of 943 kb.
Overview
MDM4 gene amplification probe is used to detect an increase in copy number of the MDM4 gene located at chromosome 1q32.1. MDM4 amplification is an oncogenic driver found in various cancers, most notably in approximately 65% of retinoblastomas.