MDM2 gene (12q15) labeled as orange, with a length of 349 kb; 12 chromosome centromere (CEP12) labeled as green.
Overview
MDM2 gene amplification probe is used to identify increased copy numbers of the MDM2 gene at chromosome 12q15, and is considered the diagnostic gold standard for distinguishing well-differentiated and dedifferentiated liposarcomas from benign lipomatous tumors.