IVD - FP185 KMT2A/AFF1 Gene Fusion Probe Detection Kit

Cat.# FP-185: KMT2A/AFF1 Gene Fusion Probe Detection Kit

[Overview]

Translocation t (4;11) (q21;q23) leads to the production of the KMT2A and AFF1 fusion gene. It accounts for approximately 5-10% of newly diagnosed cases of Acute Lymphoblastic Leukemia (ALL) mainly in children. Chromosomal translocations of the lysine methyltransferase 2A (KMT2A) gene produce KMT2A fusion proteins such as KMT2A-AFF1 (previously MLL-AF4), causing poor prognosis acute lymphoblastic leukemias (ALLs) that sometimes relapse as acute myeloid leukemias (AMLs). KMT2A-AFF1 drives leukemogenesis through direct binding and inducing the aberrant overexpression of key genes, such as the anti-apoptotic factor BCL2 and the proto-oncogene MYC.

[Download] KMT2A/AFF1 Gene Fusion Probe Instructions

[Download MSDS] MSDS