IVD - FP253 NUT(15q14) Gene Break Apart Probe Detection Kit

Cat.# FP-253: NUT(15q14) Gene Break Apart Probe Detection Kit

[Overview]

NUT carcinoma (previously known as NUT midline carcinoma) is a rare, aggressive malignancy defined by rearrangement of the NUTM1 (NUT midline carcinoma family member 1) gene on 15q14. Most commonly, NUTM1 is fused with either the bromodomain-containing 4 (BRD4) gene on 19p13.1 or the bromodomain-containing 3 (BRD3) gene on 9q34, and less commonly with the nuclear receptor binding SET domain protein 3 (NSD3) gene. Typical histologic features associated with NUT carcinoma are those of a primitive, epithelial malignancy with variable “abrupt” squamous differentiation. While initially reported in midline structures in young patients, typically in the mediastinum or upper aerodigestive tract, NUT carcinoma is being increasingly recognized in adults and in non-midline anatomic locations such as the kidney, parotid, and thigh. Prognosis is dismal, with a 6.7-month median overall survival.

 

[Download] NUT(15q14) Gene Break Apart Probe Instructions

[Download MSDS] MSDS