IVD - FP240 BCL6/IGH Gene Fusion t(3;14) Probe Detection Kit

 Cat.# FP-240: BCL6/IGH Gene Fusion t(3;14) Probe Detection Kit (IVD)

[Overview] 

The BCL6 gene located on 3q27 is translocated in 40% of diffuse large B-cell lymphomas. Reciprocal translocations can involve a number of other chromosomal locations, including 14q32 (IGH), 2p11 (IGK), and so on, all juxtaposing to 3q27. BCL6 is thought to mediate the DNA-binding activity of a number of zinc-finger transcription factors and characterizes the germinal center B-cell gene signature in microarray studies. The presence of the BCL6 translocation in DLBCL carries a favorable prognosis, in comparison with those carrying BCL2 who have a worse outcome and those with neither translocation who have an intermediate prognosis.

[Download] BCL6/IGH Gene Fusion t(3;14) Probe Instructions

[Download MSDS] MSDS