IVD - FP228 PD-L1(9p24)/ABL1(9q34) Gene Amplification Probe Detection Kit
Cat.# FP-228: PD-L1(9p24)/ABL1(9q34) Gene Amplification Probe Detection Kit
[Overview]
Chromosome 9 harbors several relevant
oncogenes related to hematolymphoid malignancies and one specific region, 9p24,
has come into the focus of attention in the last years as it contains
recurrently mutant genes of therapeutic interest. The most prominent genes of
this locus are programmed death ligands 1 and 2 (PDL1/PDL2), with the
amplification of PDL1 being a hallmark of both classical Hodgkin and primary
mediastinal B cell lymphoma, and Janus kinase 2 (JAK2), which is point-mutated
in myeloproliferative neoplasms and other myeloid malignancies, and rearranged
in PCM1-JAK2-positive myeloid/lymphoid neoplasms with eosinophila. Finally,
this locus contains the lysine (K)-specific demethylase 4C (KDM4C/JMJD2C),
which is also relevant for oncogenesis. Activation of these genes is
effectuated, as exemplified, by multiple mechanisms, which is rather unique to
oncogenes, since they are usually affected by just one type of mutation, and
points towards the central role of these genes in tumor initiation and growth.
Amplifications and, less frequently, translocations are the most common
findings for PDL1/PDL2 and JAK2 in lymphomas.
[Download] PD-L1(9p24)/ABL1(9q34) Gene Amplification Probe Instructions